The best Python newsletters

Weekly digest of Simon Willison's blog covering hands-on experiments with LLMs and coding agents, event live blogs, and short notes on new releases and tools. Readers get practical write-ups of what he built, what he learned, and roundups of links, quotes and open source releases.

Brett Cannon's blog covers Python packaging, security and governance, from proposals for reproducible builds on PyPI to his Python Packaging Council nomination. Readers get firsthand, detailed reasoning from a longtime core developer on supply-chain security and practical steps like hardening GitHub Actions publishing workflows.

A technical newsletter by a developer building Ethereum trading bots in Python and Rust, covering concentrated liquidity arbitrage math, telemetry for debugging hybrid systems, and local EVM simulation. Readers get deep, code-adjacent explanations of DeFi searcher engineering with worked examples and links to prior series.

A hands-on course that teaches Python by building a small project each day, with posts on generators, new Python releases, and decorators in a Flask-like app. Readers get runnable code, measured results and step-by-step explanations of concepts.

A multi-part hands-on series on building production-ready LLM agents with LangChain and LangGraph, covering durable state in Postgres, approval expiry, audit logging, and prompt-regression evaluation gates. Readers get concrete code-level walkthroughs of harness controls, verification loops and multi-agent orchestration.

A developer newsletter from the Ethereum Foundation's Python tooling team covering web3.py, py-evm and Python-based Ethereum development. Issues mix project announcements with practical tutorials such as explainers on EIP-7702 account abstraction and real-time event subscriptions.

Short product announcements from the creator of xlwings covering new features in xlwings Lite and the release of his book Python for Excel, 2nd Edition. Readers get a quick update on what changed and where to try it.